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Target
Ataxin-1
Ligand
BDBM446291
Substrate
n/a
Meas. Tech.
Human ATX Enzyme Inhibition Assay
IC50
2.00±n/a nM
Citation
 Hert, J; Hunziker, D; Mattei, P; Mauser, H; Tang, G; Wang, L Bicyclic derivatives US Patent  US10669268 Publication Date 6/2/2020 
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
  
Inhibitor
Name:
BDBM446291
Synonyms:
1-((3aR,8aS)-2-(1H-Benzo[d][1,2,3]triazole-5-carbonyl)octahydropyrrolo[3,4-d]azepin-6(7H)-yl)-3-(3-fluoro-4-(trifluoromethoxy)phenyl)propan-1-one | US10669268, Example 17 | US10669268, Example 17.01 | US10669268, Example 17.02 | US10669268, Example 17.03 | US10669268, Example 17.04 | US10669268, Example 17.05 | US10669268, Example 17.06 | US10669268, Example 17.07 | US10669268, Example 17.08 | US10669268, Example 17.09 | US10669268, Example 17.10 | US10669268, Example 17.11 | US10669268, Example 17.12 | US10669268, Example 17.13 | US10669268, Example 17.14 | US10669268, Example 17.15 | US10669268, Example 17.16 | US10669268, Example 17.17 | US10669268, Example 17.18 | US10669268, Example 17.19 | US10669268, Example 17.20
Type:
Small organic molecule
Emp. Form.:
C25H25F4N5O3
Mol. Mass.:
519.4913
SMILES:
Fc1cc(CCC(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)c2ccc3[nH]nnc3c2)ccc1OC(F)(F)F |r|
Structure:
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