Reaction Details Report a problem with these data
Target
Amyloid-beta precursor protein [672-713]
Ligand
BDBM446548
Substrate
n/a
Meas. Tech.
gamma-Secretase Assay
EC50
6.00±n/a nM
Citation
Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Steiner, S; Reutlinger, M Fused pyrimidine derivatives US Patent US10669276 Publication Date 6/2/2020
More Info.:
Target
Name:
Amyloid-beta precursor protein [672-713]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein aa 672-713 | Amyloid-beta protein 42
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4512.53
Organism:
Homo sapiens (Human)
Description:
P05067[672-713]
Residue:
42
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Inhibitor
Name:
BDBM446548
Synonyms:
N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7-(4-fluorophenyl)-N4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | US10669276, Example 38
Type:
Small organic molecule
Emp. Form.:
C22H17ClF2N6
Mol. Mass.:
438.86
SMILES:
Cc1cn(cn1)-c1ccc(Nc2nc3N(CCc3c(Cl)n2)c2ccc(F)cc2)cc1F