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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM446703
Substrate
n/a
Meas. Tech.
ADP-Glo Kinase Assay
IC50
6.69±n/a nM
Citation
 Lau, WC Methods, compositions, and uses of novel Fyn kinase inhibitors US Patent  US10688093 Publication Date 6/23/2020 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM446703
Synonyms:
US10688093, Compound B50 (U.S. Pat. No.-8,492,377)-(Janssen-Pharma-ceuticals) | US11701353, Compound B50 (U.S. Pat. No. 8,492,377) (Janssen Pharmaceuticals) | benzyl- 21-methoxy-5,7,19- trioxa-2,13,24,26- tetraazapenta- cyclo[18.6.2.03, 11.04,8.023,27]octacosa- 1(26),3(11),4(8),9, 20,22,24,27-octaene- 13-carboxylate
Type:
Small organic molecule
Emp. Form.:
C30H30N4O6
Mol. Mass.:
542.5824
SMILES:
COc1cc2ncnc3Nc4c5OCOc5ccc4CN(CCCCCOc1cc23)C(=O)OCc1ccccc1
Structure:
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