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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM446704
Substrate
n/a
Meas. Tech.
ADP-Glo Kinase Assay
IC50
8.00±n/a nM
Citation
 Lau, WC Methods, compositions, and uses of novel Fyn kinase inhibitors US Patent  US10688093 Publication Date 6/23/2020 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM446704
Synonyms:
9-methoxy-N-{3- methoxy-4-[3- (pyrrolidin-1-yl)propyl] phenyl}-6,6-dimethyl- 5H,6H-benzo[h] quinazolin-2-amine | US10688093, Compound CT5263-(CellTech) | US11701353, CT5263 (CellTech)
Type:
Small organic molecule
Emp. Form.:
C29H36N4O2
Mol. Mass.:
472.6217
SMILES:
COc1ccc2c(c1)-c1nc(Nc3ccc(CCCN4CCCC4)c(OC)c3)ncc1CC2(C)C
Structure:
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