Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Fyn
Ligand
BDBM446997
Substrate
n/a
Meas. Tech.
ADP-Glo Kinase Assay
IC50
102±n/a nM
Citation
 Lau, WC Methods, compositions, and uses of novel Fyn kinase inhibitors US Patent  US10688093 Publication Date 6/23/2020 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM446997
Synonyms:
N-[3-[3-(4- hydroxy-3- methoxy- phenyl)imidazo [1,2-b]pyridazin- 6-yl]phenyl] acetamide | US10688093, Compound 828_0314_0081 | US10688093, Compound BF000726454 (828_0314_0081) | US11701353, Compound 828_0314_0081
Type:
Small organic molecule
Emp. Form.:
C21H18N4O3
Mol. Mass.:
374.3926
SMILES:
COc1cc(ccc1O)-c1cnc2ccc(nn12)-c1cccc(NC(C)=O)c1
Structure:
Search PDB for entries with ligand similarity: