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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447501
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
550±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447501
Synonyms:
US10689357, Example 37
Type:
Small organic molecule
Emp. Form.:
C18H20N2O2S
Mol. Mass.:
328.429
SMILES:
COc1ccc(cc1)C12CC(C1)(C2)C(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:16.18,18.23,(-9.11,-.79,;-8.34,.54,;-6.8,.54,;-6.03,-.79,;-4.49,-.79,;-3.72,.54,;-4.49,1.88,;-6.03,1.88,;-2.18,.54,;-1.09,-.54,;,.54,;-1.09,1.63,;-1.11,.88,;1.54,.54,;2.31,1.88,;2.31,-.79,;3.85,-.79,;4.94,.3,;6.11,-.79,;4.94,-1.88,;7.65,-.79,;8.42,.54,;9.19,1.88,)|
Structure:
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