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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447505
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
55±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447505
Synonyms:
US10689357, Example 41
Type:
Small organic molecule
Emp. Form.:
C17H20N2O2S
Mol. Mass.:
316.418
SMILES:
COc1ccc(cc1)[C@@H]1C[C@@H](C1)C(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:15.16,17.21,wD:10.13,8.8,(-9.22,-3.4,;-7.89,-4.17,;-6.55,-3.4,;-6.55,-1.86,;-5.22,-1.09,;-3.89,-1.86,;-3.89,-3.4,;-5.22,-4.17,;-2.55,-1.09,;-2.15,.4,;-.67,,;-1.07,-1.49,;.67,.77,;.67,2.31,;2,,;3.33,.77,;3.73,2.26,;5.22,1.86,;4.82,.37,;6.55,2.63,;7.89,3.4,;9.22,4.17,)|
Structure:
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