Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM447997
Substrate
n/a
Meas. Tech.
GTPγS Binding
EC50
0.064±n/a nM
Citation
 Chen, Y; Cheng, AC; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Pattaropong, V; Swaminath, G; Kreiman, C; Moebius, DC; Sharma, A Triazole pyridyl compounds as agonists of the APJ receptor US Patent  US10689367 Publication Date 6/23/2020 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM447997
Synonyms:
US10689367, Example 325.0 | US10689367, Example 326.0 | US10689367, Example 327.0 | US10689367, Example 328.0
Type:
Small organic molecule
Emp. Form.:
C24H32ClN7O5S
Mol. Mass.:
566.073
SMILES:
CC[C@H]([C@@H]1CCCCO1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1 |r|
Structure:
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