Reaction Details Report a problem with these data
Target
POU domain, class 2, transcription factor 2
Ligand
BDBM448198
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
610±n/a nM
Citation
 Bacon, EM; Cai, ZR; Chen, X; Cottell, JJ; Desai, MC; Ji, M; Jin, H; Lazerwith, SE; Mish, MR; Morganelli, PA; Pyun, H; Taylor, JG; Trejo Martin, TA Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections US Patent  US10689399 Publication Date 6/23/2020 
Target
Name:
POU domain, class 2, transcription factor 2
Synonyms:
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 | OCT2 | OCT2 | OTF-2 | OTF2 | Oct-2 | Octamer-binding protein 2 | Octamer-binding transcription factor 2 | Octamer-binding transcription factor 2 (OCT2) | PO2F2_HUMAN | POU domain, class 2, transcription factor 2 | POU2F2
Type:
PROTEIN
Mol. Mass.:
51217.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109671
Residue:
479
Sequence:
MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPSTKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLSHPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
  
Inhibitor
Name:
BDBM448198
Synonyms:
US10689399, Compound 13
Type:
Small organic molecule
Emp. Form.:
C22H21F2N3O5
Mol. Mass.:
445.416
SMILES:
C[C@@H](NC(=O)c1cn2CC3O[C@@H]4CC[C@H](C4)N3C(=O)c2c(O)c1=O)c1ccc(F)cc1F |THB:8:9:12.13:15,17:16:12.13:15|
Structure:
Search PDB for entries with ligand similarity: