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Target
Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM449881
Substrate
n/a
Meas. Tech.
Kinase Assay
EC50
129±n/a nM
Citation
 Larsen, J; Larsen, M; Rasmussen, LK; Ritzen, A; Duus, TM Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof US Patent  US10703751 Publication Date 7/7/2020 
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
Homo sapiens (Human)
Description:
P23458[850-1154]
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM449881
Synonyms:
US10703751, Example 7 | cis-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(methylamino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile
Type:
Small organic molecule
Emp. Form.:
C17H23N5O
Mol. Mass.:
313.3974
SMILES:
CNc1cc2n([C@@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O |r,wU:20.24,6.5,9.9,(-2.67,-3.81,;-1.34,-4.58,;-.01,-3.81,;-.01,-2.27,;1.33,-1.5,;1.65,0,;.62,1.15,;1.09,2.61,;.06,3.76,;-1.44,3.44,;-2.48,4.58,;-3.98,4.26,;-5.49,3.94,;-1.92,1.97,;-.89,.83,;3.18,.17,;3.8,-1.24,;2.66,-2.27,;2.66,-3.81,;1.33,-4.58,;3.95,1.5,;3.18,2.83,;5.49,1.5,)|
Structure:
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