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Target
RAF proto-oncogene serine/threonine-protein kinase [325-648]
Ligand
BDBM202696
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
0.137±n/a nM
Citation
 Aversa, RJ; Barsanti, PA; Burger, MT; Dillon, MP; Dipesa, A; Hu, C; Lou, Y; Nishiguchi, GA; Pan, Y; Polyakov, VR; Ramurthy, S; Rico, AC; Setti, LQ; Smith, A; Subramanian, S; Taft, BR; Tanner, HR; Wan, L; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent  US10709712 Publication Date 7/14/2020 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [325-648]
Synonyms:
RAF | RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648) | RAF1 | RAF1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37066.83
Organism:
Homo sapiens (Human)
Description:
aa 325-648, C-Raf TR refers to a truncated
Residue:
324
Sequence:
QEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM202696
Synonyms:
US10245267, Example 43 | US10709712, Example 42 | US9242969, 42 | US9694016, 42
Type:
Small organic molecule
Emp. Form.:
C26H25F3N4O2
Mol. Mass.:
482.4975
SMILES:
CC(=C)c1cc(nc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Structure:
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