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Target
Serine/threonine-protein kinase 24
Ligand
BDBM451752
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
>1000±n/a nM
Citation
 Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent  US10710978 Publication Date 7/14/2020 
Target
Name:
Serine/threonine-protein kinase 24
Synonyms:
MST3 | STK24 | STK24_HUMAN | STK3
Type:
PROTEIN
Mol. Mass.:
49300.82
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774397
Residue:
443
Sequence:
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
  
Inhibitor
Name:
BDBM451752
Synonyms:
4-(6-amino-5-(2-methyl-1- oxo-1,2,3,4- tetrahydroisoquinolin-6- yl)pyridin-3-yl)-N- cyclopropyl-3-fluoro-N- methylbenzenesulfonamide | US10710978, Compound I-62
Type:
Small organic molecule
Emp. Form.:
C25H25FN4O3S
Mol. Mass.:
480.554
SMILES:
CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)N(C)CCc2c1
Structure:
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