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Target
ATR-interacting protein
Ligand
BDBM453040
Substrate
n/a
Meas. Tech.
ATR Activity Assay
IC50
25.9±n/a nM
Citation
 Lücking, U; Koppitz, M; Lefranc, J; Wortmann, L; Wengner, AM; Siemeister, G; Bömer, U; Bader, B; Lienau, P; Schick, H 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines US Patent  US10729680 Publication Date 8/4/2020 
Target
Name:
ATR-interacting protein
Synonyms:
AGS1 | ATM and Rad3-related-interacting protein | ATR-interacting protein (ATRIP) | ATRIP | ATRIP_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
85833.30
Organism:
Homo sapiens (Human)
Description:
Q8WXE1
Residue:
791
Sequence:
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDLEELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG
  
Inhibitor
Name:
BDBM453040
Synonyms:
5-methyl-2-[(3R)-3-methylmorpholin-4-yl]-4-(propan-2-yloxy)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine | US10729680, Example 1
Type:
Small organic molecule
Emp. Form.:
C20H25N5O2
Mol. Mass.:
367.4448
SMILES:
CC(C)Oc1cc(nc2c(ncc(C)c12)-c1ccn[nH]1)N1CCOC[C@H]1C |r|
Structure:
Search PDB for entries with ligand similarity: