Reaction Details Report a problem with these data
Target
Putative sugar transporter
Ligand
BDBM453255
Substrate
n/a
Meas. Tech.
Lactate Excretion Assays
IC50
55±n/a nM
Citation
Olszewski, K; Poyurovsky, M; Barsotti, A; Kim, J; Liu, KG Treatment of infectious diseases with glucose uptake inhibitors US Patent US10729691 Publication Date 8/4/2020
More Info.:
Target
Name:
Putative sugar transporter
Synonyms:
Hexose transporter 1
Type:
PROTEIN
Mol. Mass.:
56427.07
Organism:
Plasmodium falciparum
Description:
ChEMBL_456666
Residue:
504
Sequence:
MTKSSKDICSENEGKKNGKSGFFSTSFKYVLSACIASFIFGYQVSVLNTIKNFIVVEFEWCKGEKDRLNCSNNTIQSSFLLASVFIGAVLGCGFSGYLVQFGRRLSLLIIYNFFFLVSILTSITHHFHTILFARLLSGFGIGLVTVSVPMYISEMTHKDKKGAYGVMHQLFITFGIFVAVMLGLAMGEGPKADSTEPLTSFAKLWWRLMFLFPSVISLIGILALVVFFKEETPYFLFEKGRIEESKNILKKIYETDNVDEPLNAIKEAVEQNESAKKNSLSLLSALKIPSYRYVIILGCLLSGLQQFTGINVLVSNSNELYKEFLDSHLITILSVVMTAVNFLMTFPAIYIVEKLGRKTLLLWGCVGVLVAYLPTAIANEINRNSNFVKILSIVATFVMIISFAVSYGPVLWIYLHEMFPSEIKDSAASLASLVNWVCAIIVVFPSDIIIKKSPSILFIVFSVMSILTFFFIFFFIKETKGGEIGTSPYITMEERQKHMTKSVV
Inhibitor
Name:
BDBM453255
Synonyms:
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)phenoxy)-N-isopropylacetamide | US10729691, Example 40
Type:
Small organic molecule
Emp. Form.:
C27H28N6O3
Mol. Mass.:
484.5496
SMILES:
CC(C)NC(=O)COc1cccc(c1)-c1nc2CCOCc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1