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Target
Putative sugar transporter
Ligand
BDBM453261
Substrate
n/a
Meas. Tech.
Lactate Excretion Assays
IC50
55±n/a nM
Citation
 Olszewski, K; Poyurovsky, M; Barsotti, A; Kim, J; Liu, KG Treatment of infectious diseases with glucose uptake inhibitors US Patent  US10729691 Publication Date 8/4/2020 
Target
Name:
Putative sugar transporter
Synonyms:
Hexose transporter 1
Type:
PROTEIN
Mol. Mass.:
56427.07
Organism:
Plasmodium falciparum
Description:
ChEMBL_456666
Residue:
504
Sequence:
MTKSSKDICSENEGKKNGKSGFFSTSFKYVLSACIASFIFGYQVSVLNTIKNFIVVEFEWCKGEKDRLNCSNNTIQSSFLLASVFIGAVLGCGFSGYLVQFGRRLSLLIIYNFFFLVSILTSITHHFHTILFARLLSGFGIGLVTVSVPMYISEMTHKDKKGAYGVMHQLFITFGIFVAVMLGLAMGEGPKADSTEPLTSFAKLWWRLMFLFPSVISLIGILALVVFFKEETPYFLFEKGRIEESKNILKKIYETDNVDEPLNAIKEAVEQNESAKKNSLSLLSALKIPSYRYVIILGCLLSGLQQFTGINVLVSNSNELYKEFLDSHLITILSVVMTAVNFLMTFPAIYIVEKLGRKTLLLWGCVGVLVAYLPTAIANEINRNSNFVKILSIVATFVMIISFAVSYGPVLWIYLHEMFPSEIKDSAASLASLVNWVCAIIVVFPSDIIIKKSPSILFIVFSVMSILTFFFIFFFIKETKGGEIGTSPYITMEERQKHMTKSVV
  
Inhibitor
Name:
BDBM453261
Synonyms:
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)phenoxy)-N-isobutylacetamide | US10729691, Example 46
Type:
Small organic molecule
Emp. Form.:
C28H30N6O3
Mol. Mass.:
498.5762
SMILES:
CC(C)CNC(=O)COc1cccc(c1)-c1nc2CCOCc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1
Structure:
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