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Target
Putative sugar transporter
Ligand
BDBM453263
Substrate
n/a
Meas. Tech.
Lactate Excretion Assays
IC50
55±n/a nM
Citation
 Olszewski, K; Poyurovsky, M; Barsotti, A; Kim, J; Liu, KG Treatment of infectious diseases with glucose uptake inhibitors US Patent  US10729691 Publication Date 8/4/2020 
Target
Name:
Putative sugar transporter
Synonyms:
Hexose transporter 1
Type:
PROTEIN
Mol. Mass.:
56427.07
Organism:
Plasmodium falciparum
Description:
ChEMBL_456666
Residue:
504
Sequence:
MTKSSKDICSENEGKKNGKSGFFSTSFKYVLSACIASFIFGYQVSVLNTIKNFIVVEFEWCKGEKDRLNCSNNTIQSSFLLASVFIGAVLGCGFSGYLVQFGRRLSLLIIYNFFFLVSILTSITHHFHTILFARLLSGFGIGLVTVSVPMYISEMTHKDKKGAYGVMHQLFITFGIFVAVMLGLAMGEGPKADSTEPLTSFAKLWWRLMFLFPSVISLIGILALVVFFKEETPYFLFEKGRIEESKNILKKIYETDNVDEPLNAIKEAVEQNESAKKNSLSLLSALKIPSYRYVIILGCLLSGLQQFTGINVLVSNSNELYKEFLDSHLITILSVVMTAVNFLMTFPAIYIVEKLGRKTLLLWGCVGVLVAYLPTAIANEINRNSNFVKILSIVATFVMIISFAVSYGPVLWIYLHEMFPSEIKDSAASLASLVNWVCAIIVVFPSDIIIKKSPSILFIVFSVMSILTFFFIFFFIKETKGGEIGTSPYITMEERQKHMTKSVV
  
Inhibitor
Name:
BDBM453263
Synonyms:
2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-acetyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(tert-butyl)acetamide | US10729691, Example 48
Type:
Small organic molecule
Emp. Form.:
C30H33N7O3
Mol. Mass.:
539.6281
SMILES:
CC(=O)N1CCc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2C1)-c1cccc(OCC(=O)NC(C)(C)C)c1
Structure:
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