Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM454980
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance Assay
Kd
240±n/a nM
Citation
 Crew, APCrews, CMChen, XDong, HFerraro, CQian, YSiu, KWang, JJin, MBerlin, MZimmermann, KSnyder, L Compounds and methods for the enhanced degradation of targeted proteins US Patent  US10730870 Publication Date 8/4/2020 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM454980
Synonyms:
US10730870, Example 207
Type:
Small organic molecule
Emp. Form.:
C27H34N4O4S
Mol. Mass.:
510.648
SMILES:
CC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)c1cc(C)no1)c1ccc(cc1)-c1scnc1C |r|
Structure:
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