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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM455771
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Vechorkin, O; Atasoylu, O; Ye, HF; Liu, K; Zhang, K; Yao, W Cyanoindazole compounds and uses thereof US Patent  US10722495 Publication Date 7/28/2020 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM455771
Synonyms:
US10722495, Example 18
Type:
Small organic molecule
Emp. Form.:
C24H21FN4O2S
Mol. Mass.:
448.513
SMILES:
CNCc1cc(C)c(c(F)c1)-c1cc2c(n[nH]c2cc1C#N)-c1ccc(cc1)S(C)(=O)=O |(-.34,5.07,;-1.67,5.84,;-3,5.07,;-3,3.53,;-1.67,2.76,;-1.67,1.22,;-.34,.45,;-3,.45,;-4.34,1.22,;-5.67,.45,;-4.34,2.76,;-3,-1.09,;-1.67,-1.86,;-1.67,-3.4,;-.53,-4.43,;-1.15,-5.84,;-2.68,-5.68,;-3,-4.17,;-4.34,-3.4,;-4.34,-1.86,;-5.67,-1.09,;-7.01,-.32,;.98,-4.11,;2.01,-5.26,;3.52,-4.94,;4.05,-3.46,;2.96,-2.33,;1.46,-2.65,;5.55,-3.14,;5.23,-1.63,;7.06,-2.82,;5.87,-4.65,)|
Structure:
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