Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM456055
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
0.600±n/a nM
Citation
 Oden, LS; Nilsson, M; Kahnberg, P; Samuelsson, B; Grabowska, U Protease inhibitors US Patent  US10723709 Publication Date 7/28/2020 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM456055
Synonyms:
US10723709, Example 5
Type:
Small organic molecule
Emp. Form.:
C30H34FN5O4S
Mol. Mass.:
579.685
SMILES:
CN1CCN(CC1)c1nc(c(F)s1)-c1ccc(cc1)C(=O)NC(C=O)(C1CCCC1)N1CC(C#C)C2OCC(=O)C12
Structure:
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