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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM456149
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
1.000±n/a nM
Citation
 Gunaga, P; Bhide, RS; Bora, RO; Panda, M; Yadav, ND; Priestley, ES; Richter, J Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors US Patent  US10723723 Publication Date 7/28/2020 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM456149
Synonyms:
US10723723, Example 35
Type:
Small organic molecule
Emp. Form.:
C23H23N5O4
Mol. Mass.:
433.4598
SMILES:
COc1c(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cnn1-c1cc(C)c(cn1)C#N |r|
Structure:
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