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Target
Cyclic GMP-AMP synthase [155-522]
Ligand
BDBM457201
Substrate
n/a
Meas. Tech.
Biochemical Activity Assay
IC50
<20±n/a nM
Citation
 Ndubaku, CO; Katibah, GE; Roberts, TC; Sung, L; Ciblat, S; Raeppel, F; Ly, VL; Ramtohul, YK; Rybak, T; Zaky, M; Gillard, L; Ismaili, H Pyrazolopyrimidinone compounds and uses thereof US Patent  US10738056 Publication Date 8/11/2020 
Target
Name:
Cyclic GMP-AMP synthase [155-522]
Synonyms:
C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase (CGAS) (155-522) | MB21D1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43018.25
Organism:
Homo sapiens (Human)
Description:
Q8N884[155-522]
Residue:
368
Sequence:
RRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
  
Inhibitor
Name:
BDBM457201
Synonyms:
US10738056, Compound A1069
Type:
Small organic molecule
Emp. Form.:
C21H16F3N5O2
Mol. Mass.:
427.3792
SMILES:
Cc1[nH]c2c(c(nn2c(=O)c1C(=O)Nc1cccc(N)c1)C(F)(F)F)-c1ccccc1
Structure:
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