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Target
Tyrosine-protein kinase JAK1 [866-1154]
Ligand
BDBM127750
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1000±n/a nM
Citation
 Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent  US10758542 Publication Date 9/1/2020 
Target
Name:
Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:
JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:
Protein
Mol. Mass.:
33185.74
Organism:
Homo sapiens (Human)
Description:
P23458[866-1154]
Residue:
289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM127750
Synonyms:
US10251889, Example 123 | US10758542, Example 123 | US8791123, 123 | US9782415, Example 123 | US9796724, Example 123
Type:
Small organic molecule
Emp. Form.:
C21H23FN6O
Mol. Mass.:
394.4453
SMILES:
C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1 |r|
Structure:
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