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Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM127750
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1000±n/a nM
Citation
 Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent  US10758542 Publication Date 9/1/2020 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM127750
Synonyms:
US10251889, Example 123 | US10758542, Example 123 | US8791123, 123 | US9782415, Example 123 | US9796724, Example 123
Type:
Small organic molecule
Emp. Form.:
C21H23FN6O
Mol. Mass.:
394.4453
SMILES:
C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1 |r|
Structure:
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