Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM408663
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
18.7±n/a nM
Citation
 Li, X; Dong, Q; Sun, P Pharmaceutical uses of pyridine carboxamide derivatives US Patent  US10759788 Publication Date 9/1/2020 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-sensitive inward rectifier potassium channel 1 | Inward rectifier K(+) channel Kir1.1 | KAB-1 | KCNJ1_RAT | Kcnj1 | Potassium channel (ATP modulatory) | Potassium channel, inwardly rectifying subfamily J member 1 | Renal Outer Medullary Potassium (ROMK) | Renal Outer Medullary Potassium (ROMK1) | Romk1 | The Renal Outer Medullary Potassium (ROMK) channel (Kir1.1)
Type:
Enzyme
Mol. Mass.:
44976.27
Organism:
Rattus norvegicus (Rat)
Description:
P35560
Residue:
391
Sequence:
MGASERSVFRVLIRALTERMFKHLRRWFITHIFGRSRQRARLVSKEGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM
  
Inhibitor
Name:
BDBM408663
Synonyms:
(R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperidin-4-yl)-4-methoxypicolinamide | US10364234, Example 1 | US10759788, Example 1
Type:
Small organic molecule
Emp. Form.:
C24H26N4O5
Mol. Mass.:
450.487
SMILES:
COc1cc(ncc1C#N)C(=O)NC1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1 |r|
Structure:
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