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Target
Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM458908
Substrate
n/a
Meas. Tech.
In Vitro JAK kinase Assays
IC50
7.00±n/a nM
Citation
 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent  US10759793 Publication Date 9/1/2020 
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (850-1154)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
n/a
Description:
aa 850-1154
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
 
Inhibitor
Name:
BDBM458908
Synonyms:
US10759793, Example 54
Type:
Small organic molecule
Emp. Form.:
C23H22FN9O2
Mol. Mass.:
475.4783
SMILES:
OCCOc1nc(nc(N[C@@H]2CCCN(C2)c2cnc(cn2)C#N)c1F)-c1cnn2ccccc12
Structure:
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