Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM101066
Substrate
n/a
Meas. Tech.
Omnia Assay Protocol for Potency Assessment Against (method a)
IC50
<100.0±n/a nM
Citation
 D''Agostino, LA; Sjin, RT; Niu, D; McDonald, JJ; Zhu, Z; Liu, H; Mazdiyasni, H; Petter, RC; Singh, J; Barrague, M; Gross, A; Munson, M Heteroaryl compounds and uses thereof US Patent  US10774052 Publication Date 9/15/2020 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM101066
Synonyms:
US10189794, Compound I-244 | US10618902, Compound I-244 | US10774052, Compound I-244 | US9695132, I-244
Type:
Small organic molecule
Emp. Form.:
C25H21Cl2N5O4
Mol. Mass.:
526.371
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3NC(=O)C=C)nc2n(C)c1=O |(8.89,2.18,;7.56,1.41,;6.22,2.18,;6.22,3.72,;4.89,4.49,;4.89,6.03,;6.22,6.8,;3.56,3.72,;2.22,4.49,;3.56,2.18,;4.89,1.41,;4.89,-.13,;2.22,1.41,;.89,2.18,;-.44,1.41,;-1.78,2.18,;-3.11,1.41,;-3.11,-.13,;-4.45,-.9,;-4.45,-2.44,;-3.11,-3.21,;-3.11,-4.75,;-4.45,-5.52,;-5.78,-4.75,;-5.78,-3.21,;-7.11,-2.44,;-8.45,-3.21,;-8.45,-4.75,;-9.78,-2.44,;-11.11,-3.21,;-1.78,-.9,;-.44,-.13,;.89,-.9,;.89,-2.44,;2.22,-.13,;3.56,-.9,)|
Structure:
Search PDB for entries with ligand similarity: