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Target
Fibroblast growth factor receptor 1 [308-731]
Ligand
BDBM350016
Substrate
n/a
Meas. Tech.
LanthaScreen Assay
IC50
17.4±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 1 [308-731]
Synonyms:
BFGFR | CEK | FGFBR | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731) | HBGFR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47326.25
Organism:
Homo sapiens (Human)
Description:
aa 308-731
Residue:
424
Sequence:
VQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYM
  
Inhibitor
Name:
BDBM350016
Synonyms:
6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazin-2-yl)-2- (3,5- dimethoxyphenyl)pyridazin- 3(2H)-one 2,2,2-trifluoroacetate | US10208024, Example 15 | US10766881, Example 15
Type:
Small organic molecule
Emp. Form.:
C22H23N7O3
Mol. Mass.:
433.4631
SMILES:
COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C(C)C
Structure:
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