Reaction Details Report a problem with these data
Target
SUMO-activating enzyme subunit 1
Ligand
BDBM462707
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Duffey, MO; England, D; Freeze, BS; Hu, Z; Langston, S; McIntyre, C; Mizutani, H; Ono, K; Xu, H Heteroaryl compounds useful as inhibitors of SUMO activating enzyme US Patent  US10780090 Publication Date 9/22/2020 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM462707
Synonyms:
US10780090, Compound I-45 | {(1R,2S,4R)-2-hydroxy-4-[(5-{[5-methyl-4-(3-methylbenzyl)-2- thienyl]carbonyl}pyrimidin-4-yl)amino]cyclopentyl}methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C24H28N4O5S2
Mol. Mass.:
516.633
SMILES:
Cc1sc(cc1Cc1cccc(C)c1)C(=O)c1cncnc1N[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)C1
Structure:
Search PDB for entries with ligand similarity: