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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM462731
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Duffey, MO; England, D; Freeze, BS; Hu, Z; Langston, S; McIntyre, C; Mizutani, H; Ono, K; Xu, H Heteroaryl compounds useful as inhibitors of SUMO activating enzyme US Patent  US10780090 Publication Date 9/22/2020 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM462731
Synonyms:
US10780090, Compound I-65 | [(1R,2R,3R,4R)-3-fluoro-2-hydroxy-4-({5-[5-methyl-4-(3-methylbenzyl)-2- furoyl]pyrimidin-4-yl}amino)cyclopentyl]methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C24H27FN4O6S
Mol. Mass.:
518.558
SMILES:
Cc1oc(cc1Cc1cccc(C)c1)C(=O)c1cncnc1N[C@@H]1C[C@H](COS(N)(=O)=O)[C@@H](O)[C@@H]1F
Structure:
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