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Target
Guanylate cyclase soluble subunit alpha-1
Ligand
BDBM463267
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
10.9±n/a nM
Citation
 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators US Patent  US10780092 Publication Date 9/22/2020 
Target
Name:
Guanylate cyclase soluble subunit alpha-1
Synonyms:
GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:
Enzyme
Mol. Mass.:
77457.21
Organism:
Homo sapiens (Human)
Description:
Q02108
Residue:
690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
  
Inhibitor
Name:
BDBM463267
Synonyms:
4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-{8-[(4-methyl- cyclohexyl)methyl]- imidazo[1,2-a]pyrazin- 6-yl}-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one | US10780092, Example 120-BA | US10780092, Example 120-BB
Type:
Small organic molecule
Emp. Form.:
C27H28ClN7O2
Mol. Mass.:
518.01
SMILES:
CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(Cl)c2)CC1 |(1.21,-7.04,;-.12,-6.27,;-1.46,-7.04,;-2.79,-6.27,;-2.79,-4.73,;-4.12,-3.96,;-4.12,-2.42,;-2.79,-1.65,;-2.79,-.11,;-4.12,.66,;-5.46,-.11,;-6.92,.37,;-7.83,-.88,;-6.92,-2.12,;-5.46,-1.65,;-1.46,.66,;-.12,-.11,;1.21,.66,;2.67,.19,;3.58,1.43,;5.12,1.43,;2.67,2.68,;2.28,4.17,;1.21,2.2,;-.12,2.97,;-.12,4.51,;-1.46,2.2,;3.76,3.77,;3.37,5.26,;4.45,6.35,;5.94,5.95,;7.03,7.04,;6.34,4.46,;7.83,4.06,;5.25,3.37,;-1.46,-3.96,;-.12,-4.73,)|
Structure:
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