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Target
Prokineticin receptor 2
Ligand
BDBM463309
Substrate
n/a
Meas. Tech.
Aequorin-Based Luminescent Assay
Ki
2.10±n/a nM
Citation
 Zhou, Q Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists US Patent  US10780095 Publication Date 9/22/2020 
Target
Name:
Prokineticin receptor 2
Synonyms:
G-protein coupled receptor 73-like 1 | GPR73L1 | GPR73b | GPRg2 | PKR2 | PKR2_HUMAN | PROKR2 | Prokineticin Receptor 2 (PKR2)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44009.48
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed on membranes from CHO cells stably transfected with PKR2.
Residue:
384
Sequence:
MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
  
Inhibitor
Name:
BDBM463309
Synonyms:
(+-)-2-Methyl-3-(benzimidazol- 4-ylmethylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide | US10780095, Structure TABLE 1.7
Type:
Small organic molecule
Emp. Form.:
C26H33ClN4O3
Mol. Mass.:
485.018
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2nc[nH]c12
Structure:
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