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Target
Prokineticin receptor 1
Ligand
BDBM463312
Substrate
n/a
Meas. Tech.
Aequorin-Based Luminescent Assay
Ki
8.40±n/a nM
Citation
 Zhou, Q Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists US Patent  US10780095 Publication Date 9/22/2020 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM463312
Synonyms:
(-)-(2R)-1-(benzimidazol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-2- carboxamide | US10780095, Structure TABLE 1.10
Type:
Small organic molecule
Emp. Form.:
C27H33ClN4O4
Mol. Mass.:
513.028
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3nc[nH]c23)CCO1
Structure:
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