Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464442
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
28.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464442
Synonyms:
US10793528, Example SC_5012
Type:
Small organic molecule
Emp. Form.:
C28H39N5O3
Mol. Mass.:
493.641
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCC(=O)NCc3cnco3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(4.23,5.16,;5.32,4.07,;6.81,4.47,;4.93,2.58,;4.93,1.04,;3.59,.27,;2.26,1.04,;.85,1.67,;-.18,.52,;-1.71,.68,;-2.62,-.56,;-4.15,-.4,;-4.77,1.01,;-5.05,-1.65,;-6.58,-1.49,;-7.49,-2.73,;-7.01,-4.2,;-8.26,-5.1,;-9.51,-4.2,;-9.03,-2.73,;.59,-.81,;-.04,-2.22,;2.1,-.49,;3.24,-1.52,;2.92,-3.03,;1.63,-3.87,;2.47,-5.16,;3.76,-4.32,;2.26,2.58,;3.59,3.35,;6.45,2.38,;7.04,.96,;8.57,.76,;9.51,1.98,;8.92,3.4,;7.39,3.6,)|
Structure:
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