Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM464591
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
13.0±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793556 Publication Date 10/6/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM464591
Synonyms:
CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-3-(2-methylsulfonyl- ethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10793556, Example SC_4011
Type:
Small organic molecule
Emp. Form.:
C24H37N3O4S
Mol. Mass.:
463.633
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CCS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:3.2,6.17,(11.74,2.89,;10.26,3.29,;9.86,4.77,;9.17,2.2,;8.4,.86,;6.86,.86,;6.09,2.2,;5.18,3.44,;3.72,2.97,;2.63,4.06,;1.14,3.66,;.05,4.75,;.45,6.23,;-1.44,4.35,;-.35,3.26,;3.72,1.43,;2.47,.52,;5.18,.95,;5.66,-.51,;4.63,-1.66,;3.82,-.35,;3.14,-2.06,;3.54,-3.54,;5.03,-3.15,;6.86,3.53,;8.4,3.53,;10.26,1.11,;9.86,-.38,;10.95,-1.47,;12.43,-1.07,;12.83,.42,;11.74,1.51,)|
Structure:
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