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Target
Adenosine receptor A1
Ligand
BDBM464677
Substrate
n/a
Meas. Tech.
Radioligand Binding Competition Assay
IC50
181±n/a nM
Citation
 Pham, SM; Chen, J; Ansari, A; Jadhavar, PS; Patil, VS; Khan, F; Ramachandran, SA; Agarwal, AK; Chakravarty, S 1,8-naphthyridinone compounds and uses thereof US Patent  US10793561 Publication Date 10/6/2020 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM464677
Synonyms:
US10793561, Compound 1.5
Type:
Small organic molecule
Emp. Form.:
C24H17N3O2
Mol. Mass.:
379.4107
SMILES:
COc1ccc2cc(ccc2n1)-c1cc2c(nc1-c1ccccc1)[nH]ccc2=O
Structure:
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