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Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM399766
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
<0.1±n/a nM
Citation
 Greenwood, JR; Harriman, GC; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent  US10793574 Publication Date 10/6/2020 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM399766
Synonyms:
US10323036, Compound VIII-14 | US10793574, Compound VIII-14 | US11220508, Compound VIII-14
Type:
Small organic molecule
Emp. Form.:
C24H24N10O3
Mol. Mass.:
500.5126
SMILES:
COc1c(Nc2cc(Nc3cc(C)nc(C)n3)ncc2-c2nnc(CO)o2)cccc1-c1ncn(C)n1
Structure:
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