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Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM466268
Substrate
n/a
Meas. Tech.
Inhibitory Assay
IC50
150±n/a nM
Citation
 Okuyama, M; Fukunaga, K; Usui, K; Hayashi, N; Iijima, D; Horiuchi, H; Fujimoto, N Bicyclic heterocyclic compound US Patent  US10793582 Publication Date 10/6/2020 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM466268
Synonyms:
(R)—N-benzyl-1-[7-ethyl-5-(2H-1,2,3-triazol-2-yl)[1,3]thiazolo[4,5-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide | US10793582, Example 101
Type:
Small organic molecule
Emp. Form.:
C21H22N8OS
Mol. Mass.:
434.517
SMILES:
CCc1nc(nc2nc(sc12)N1CCC[C@@H]1C(=O)NCc1ccccc1)-n1nccn1 |r|
Structure:
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