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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM466763
Substrate
n/a
Meas. Tech.
HPK1 Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Vechorkin, O; Pan, J; Sokolsky, A; Styduhar, E; Yao, W Carboxamide compounds and uses thereof US Patent  US10800761 Publication Date 10/13/2020 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM466763
Synonyms:
US10800761, Example 82
Type:
Small organic molecule
Emp. Form.:
C30H27FN6O2
Mol. Mass.:
522.5728
SMILES:
COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccc(cc1[C@H]1CC[C@H](N)CC1)-c1cnccc1C#N |r,wU:24.26,wD:27.30,(-8,-5.4,;-6.67,-6.17,;-5.33,-5.4,;-5.33,-3.86,;-4,-3.09,;-2.67,-3.86,;-2.67,-5.4,;-1.33,-6.17,;-4,-6.17,;-4,-7.71,;-5.33,-8.48,;-5.33,-10.02,;-4,-10.79,;-2.67,-10.02,;-2.67,-8.48,;-1.33,-10.79,;-1.33,-12.33,;,-10.02,;1.33,-10.79,;1.33,-12.33,;2.67,-13.1,;4,-12.33,;4,-10.79,;2.67,-10.02,;2.67,-8.48,;1.33,-7.71,;1.33,-6.17,;2.67,-5.4,;2.67,-3.86,;4,-6.17,;4,-7.71,;5.33,-13.1,;6.67,-12.33,;8,-13.1,;8,-14.64,;6.67,-15.41,;5.29,-14.66,;3.95,-15.43,;2.62,-16.2,)|
Structure:
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