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Target
Beta-lactamase TEM
Ligand
BDBM466970
Substrate
n/a
Meas. Tech.
Inhibition of Beta-Lactamase Enzymes
IC50
47.0±n/a nM
Citation
 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Beta-lactamase inhibitor compounds US Patent  US10800778 Publication Date 10/13/2020 
Target
Name:
Beta-lactamase TEM
Synonyms:
BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla
Type:
Enzyme
Mol. Mass.:
31512.33
Organism:
Escherichia coli
Description:
P62593
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM466970
Synonyms:
2-(((2S,5R)-2-(2-acetylhydrazinecarbonyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid lithium salt | US10800778, Example 27
Type:
Small organic molecule
Emp. Form.:
C12H15FN4O6
Mol. Mass.:
330.2691
SMILES:
CC(=O)NNC(=O)[C@H]1N2C[C@@H](C=C1C)N(OC(F)C(O)=O)C2=O |r,c:11|
Structure:
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