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Target
Dipeptidyl peptidase 4
Ligand
BDBM468977
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay of DPP-4
IC50
2.03±n/a nM
Citation
 Ho, KK; Quan, W; Zhou, J Pyrrolidinone compounds US Patent  US10807971 Publication Date 10/20/2020 
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
Cd26 | DPP4_MOUSE | Dipeptidyl peptidase IV | Dpp4
Type:
PROTEIN
Mol. Mass.:
87433.73
Organism:
Mus musculus
Description:
ChEMBL_1335112
Residue:
760
Sequence:
MKTPWKVLLGLLGVAALVTIITVPIVLLSKDEAAADSRRTYSLADYLKSTFRVKSYSLWWVSDFEYLYKQENNILLLNAEHGNSSIFLENSTFESFGYHSVSPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRQLITEEKIPNNTQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHRITSTGEENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNIDSLSSSSSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCPSEQQHVEMSTTGWVGRFRPAEPHFTSDGSSFYKIISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEALTSDYLYYISNQYKEMPGGRNLYKIQLTDHTNVKCLSCDLNPERCQYYAVSFSKEAKYYQLGCWGPGLPLYTLHRSTDHKELRVLEDNSALDRMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADASFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPIPEDNLDHYRNSTVMSRAEHFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLH
  
Inhibitor
Name:
BDBM468977
Synonyms:
1-[2-[(3R,5S,6R)-5-Aamino- 6-(2,5- difluorophenyl)tetrahydropyran- 3-yl]-3,4-dihydropyrazol-3- yl]-N-[(3,5-dichloro-2-fluoro- phenyl)methyl]-3-hydroxy-2- oxo-pyrrolidine-3 carboxamide, isomer 1 hydrochloride | US10807971, Example 13
Type:
Small organic molecule
Emp. Form.:
C26H24Cl2F3N5O4
Mol. Mass.:
598.401
SMILES:
N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2F)C1=O |r|
Structure:
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