Reaction Details Report a problem with these data
Target
Protein-lysine 6-oxidase
Ligand
BDBM469004
Substrate
n/a
Meas. Tech.
LOX Enzyme Activity Assay
IC50
480±n/a nM
Citation
 Springer, C; Marais, R; Niculescu-Duvaz, D; Leung, L; Smithen, D; Callens, C; Tang, H Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer US Patent  US10807974 Publication Date 10/20/2020 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
LOX | LYOX_PIG
Type:
PROTEIN
Mol. Mass.:
28737.77
Organism:
Sus scrofa
Description:
ChEMBL_108023
Residue:
246
Sequence:
DDPYNPYKYSDDNPYYNYYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM469004
Synonyms:
US10807974, Example 5 | US10995088, Example 5 | US11608330, Example 5
Type:
Small organic molecule
Emp. Form.:
C12H13NO4S3
Mol. Mass.:
331.431
SMILES:
CS(=O)(=O)c1ccc(cc1)S(=O)(=O)c1ccc(CN)s1
Structure:
Search PDB for entries with ligand similarity: