Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469351
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.30±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469351
Synonyms:
US10807988, Example SC_3002 | cis-5-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyrazine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C26H32N6O
Mol. Mass.:
444.5719
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(cn2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(6.58,8.1,;5.1,8.5,;4.7,9.99,;4.01,7.41,;3.24,6.08,;1.7,6.08,;.93,7.41,;.02,8.66,;-1.44,8.18,;-1.44,6.64,;-2.69,5.74,;.02,6.17,;.5,4.7,;-.53,3.56,;-2.07,3.56,;-2.07,2.02,;-.53,2.02,;-2.69,9.09,;-4.1,8.46,;-5.34,9.37,;-5.18,10.9,;-3.77,11.52,;-2.53,10.62,;-6.43,11.8,;-7.67,12.71,;1.7,8.75,;3.24,8.75,;5.1,6.32,;4.7,4.84,;5.79,3.75,;7.27,4.15,;7.67,5.63,;6.58,6.72,)|
Structure:
Search PDB for entries with ligand similarity: