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Target
Nociceptin receptor
Ligand
BDBM469354
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.700±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469354
Synonyms:
US10807988, Example SC_3005 | cis-5-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyrimidine-2-carboxylic acid amide
Type:
Small organic molecule
Emp. Form.:
C26H34N6O2
Mol. Mass.:
462.5872
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C(N)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(6.39,21.95,;4.9,22.35,;4.5,23.83,;3.81,21.26,;3.04,19.92,;1.5,19.92,;.73,21.26,;-.17,22.5,;-1.64,22.03,;-1.64,20.49,;-2.88,19.58,;-.17,20.01,;.31,18.55,;-.73,17.4,;-2.27,17.4,;-2.27,15.86,;-.73,15.86,;-2.72,23.12,;-2.33,24.6,;-3.41,25.69,;-4.9,25.29,;-5.3,23.81,;-4.21,22.72,;-5.99,26.38,;-5.59,27.87,;-7.48,25.98,;1.5,22.59,;3.04,22.59,;4.9,20.17,;4.5,18.68,;5.59,17.59,;7.08,17.99,;7.48,19.48,;6.39,20.57,)|
Structure:
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