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Target
Nociceptin receptor
Ligand
BDBM469362
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.20±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469362
Synonyms:
US10807988, Example SC_3012 | cis-5-[1-(Cyclobutyl-methyl)-8-methylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-4-methoxy-pyrimidine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C26H32N6O2
Mol. Mass.:
460.5713
SMILES:
CN[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2OC)C#N)CC1)c1ccccc1 |r,wU:5.10,2.1,(4.07,-18.97,;4.84,-20.31,;4.07,-21.64,;3.3,-22.97,;1.76,-22.97,;.99,-21.64,;.09,-20.39,;-1.38,-20.87,;-1.38,-22.41,;-2.62,-23.32,;.09,-22.89,;.56,-24.35,;-.47,-25.5,;-2.01,-25.5,;-2.01,-27.04,;-.47,-27.04,;-2.62,-19.96,;-4.03,-20.59,;-5.27,-19.69,;-5.11,-18.15,;-3.71,-17.53,;-2.46,-18.43,;-1.05,-17.81,;-1.05,-16.27,;-6.36,-17.25,;-7.6,-16.34,;1.76,-20.31,;3.3,-20.31,;4.84,-22.97,;4.07,-24.31,;4.84,-25.64,;6.38,-25.64,;7.15,-24.31,;6.38,-22.97,)|
Structure:
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