Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469364
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.40±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469364
Synonyms:
US10807988, Example SC_3013 | cis-5-[8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyrimidine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C26H32N6O2
Mol. Mass.:
460.5713
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(O)CCC2)c2cnc(nc2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(3.91,23.35,;4.68,22.02,;6.22,22.02,;3.91,20.69,;3.14,19.35,;1.6,19.35,;.83,20.69,;-.08,21.93,;-1.54,21.46,;-1.54,19.92,;-2.79,19.01,;-.08,19.44,;.4,17.98,;-.63,16.83,;.86,16.43,;-2.17,16.83,;-2.17,15.29,;-.63,15.29,;-2.63,22.55,;-2.23,24.03,;-3.32,25.12,;-4.81,24.72,;-5.21,23.24,;-4.12,22.15,;-5.9,25.81,;-6.99,26.9,;1.6,22.02,;3.14,22.02,;4.68,19.35,;3.91,18.02,;4.68,16.69,;6.22,16.69,;6.99,18.02,;6.22,19.35,)|
Structure:
Search PDB for entries with ligand similarity: