Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469374
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.80±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469374
Synonyms:
US10807988, Example SC_3021 | cis-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C28H36N4O2
Mol. Mass.:
460.611
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ccc(cc2)C(N)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.65,22.35,;5.42,21.02,;6.96,21.02,;4.65,19.68,;3.88,18.35,;2.34,18.35,;1.57,19.68,;.66,20.93,;-.8,20.45,;-.8,18.91,;-2.05,18.01,;.66,18.44,;1.14,16.97,;.11,15.83,;-1.43,15.83,;-1.43,14.29,;.11,14.29,;-2.05,21.36,;-1.89,22.89,;-3.13,23.8,;-4.54,23.17,;-4.7,21.64,;-3.45,20.73,;-5.79,24.08,;-7.19,23.45,;-5.62,25.61,;2.34,21.02,;3.88,21.02,;5.42,18.35,;4.65,17.02,;5.42,15.68,;6.96,15.68,;7.73,17.02,;6.96,18.35,)|
Structure:
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