Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469382
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.600±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469382
Synonyms:
US10807988, Example SC_3028 | cis-4-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N,N-dimethyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C30H40N4O2
Mol. Mass.:
488.6642
SMILES:
CN(C)C(=O)c1ccc(cc1)N1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:13.30,16.20,(-8.08,-16.17,;-6.84,-17.07,;-7,-18.61,;-5.43,-16.45,;-5.27,-14.92,;-4.18,-17.35,;-2.78,-16.73,;-1.53,-17.63,;-1.69,-19.16,;-3.1,-19.79,;-4.35,-18.89,;-.45,-20.07,;1.02,-19.59,;1.92,-20.84,;2.69,-22.17,;4.23,-22.17,;5,-20.84,;4.23,-19.51,;2.69,-19.51,;5.77,-19.51,;5,-18.17,;7.31,-19.51,;5.77,-22.17,;5,-23.51,;5.77,-24.84,;7.31,-24.84,;8.08,-23.51,;7.31,-22.17,;1.02,-22.09,;1.49,-23.55,;.46,-24.69,;-1.08,-24.69,;-1.08,-26.23,;.46,-26.23,;-.45,-21.61,;-1.69,-22.51,)|
Structure:
Search PDB for entries with ligand similarity: