Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469405
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469405
Synonyms:
US10807988, Example SC_3048 | cis-4-[1-(Cyclobuty1-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyrimidine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C26H32N6O
Mol. Mass.:
444.5719
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ccnc(n2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(5.33,-24.84,;3.85,-24.44,;3.45,-22.95,;2.76,-25.53,;1.99,-26.86,;.45,-26.86,;-.32,-25.53,;-1.23,-24.28,;-2.69,-24.76,;-2.69,-26.3,;-3.94,-27.2,;-1.23,-26.78,;-.75,-28.24,;-1.78,-29.38,;-3.32,-29.38,;-3.32,-30.92,;-1.78,-30.92,;-3.78,-23.67,;-5.27,-24.07,;-6.36,-22.98,;-5.96,-21.49,;-4.47,-21.09,;-3.38,-22.18,;-4.07,-19.61,;-3.67,-18.12,;.45,-24.2,;1.99,-24.2,;3.69,-26.75,;3.1,-28.17,;4.04,-29.4,;5.57,-29.2,;6.16,-27.77,;5.22,-26.55,)|
Structure:
Search PDB for entries with ligand similarity: