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Target
Nociceptin receptor
Ligand
BDBM469419
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.700±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469419
Synonyms:
US10807988, Example SC_3063 | cis-5-[1-[(1-Cyano-cyclobutyl)-methyl]-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyridine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C28H32N6O
Mol. Mass.:
468.5933
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(CCC2)C#N)c2ccc(nc2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.15,11.34,;4.92,10,;6.46,10,;4.15,8.67,;3.38,7.34,;1.84,7.34,;1.07,8.67,;.17,9.92,;-1.3,9.44,;-1.3,7.9,;-2.54,6.99,;.17,7.42,;.64,5.96,;-.39,4.81,;-1.93,4.81,;-1.93,3.27,;-.39,3.27,;.95,4.04,;2.28,3.27,;-2.39,10.53,;-1.99,12.02,;-3.08,13.1,;-4.56,12.71,;-4.96,11.22,;-3.87,10.13,;-5.9,13.48,;-7.23,14.25,;1.84,10,;3.38,10,;4.92,7.34,;4.15,6,;4.92,4.67,;6.46,4.67,;7.23,6,;6.46,7.34,)|
Structure:
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