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Target
Nociceptin receptor
Ligand
BDBM469432
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469432
Synonyms:
US10807988, Example SC_3073 | cis-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl-3-[2-(trifluoromethyl)- pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C26H32F3N5O
Mol. Mass.:
487.5604
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(2.77,-19.58,;3.54,-20.91,;5.08,-20.91,;2.77,-22.25,;2,-23.58,;.46,-23.58,;-.31,-22.25,;-1.22,-21,;-2.68,-21.48,;-2.68,-23.02,;-3.93,-23.92,;-1.22,-23.49,;-.74,-24.96,;-1.77,-26.1,;-3.31,-26.1,;-3.31,-27.64,;-1.77,-27.64,;-3.77,-20.39,;-3.37,-18.9,;-4.46,-17.81,;-5.95,-18.21,;-6.35,-19.7,;-5.26,-20.78,;-7.04,-17.12,;-8.12,-16.03,;-5.95,-16.03,;-8.12,-18.21,;.46,-20.91,;2,-20.91,;3.54,-23.58,;2.77,-24.91,;3.54,-26.25,;5.08,-26.25,;5.85,-24.91,;5.08,-23.58,)|
Structure:
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